Spruce Avenue, established as a neighbourhood in 1981, is centrally located in Edmonton and is home to significant institutions like Kingsway Garden Mall and the Northern Alberta Institute of Technology.
Spruce Avenue's central location has made it a hub for various important facilities, including Kingsway Garden Mall, The Northern Alberta Institute of Technology, and the Municipal Airport. The neighbourhood also hosts the Glenrose Rehabilitation Hospital, which was originally the Royal Alexandra and one of Edmonton's largest healthcare facilities until its replacement was built.
With a notable age-sex composition, Spruce Avenue has a high proportion of residents aged 70 years or older, likely due to the presence of an extended care facility in the area. The neighbourhood derives its name from the former designation for 114 Avenue, reflecting its historical roots within the city.